Himanshu Joshi

e-mail: 
hjoshi@illinois.edu
phone: 
(217) 265-6438
office: 
261 LLP

Loomis Laboratory of Physics
1110 West Green Street
Urbana, IL 61801-3080

I am a postdoctoral fellow in the Department of Physics at the University of Illinois at Urbana-Champaign with Prof Aleksei Aksimentiev. I am a computational biophysicist by training and obtained my Ph.D. from the Physics Department of IISc Bangalore in 2017. My research interest involves the multiscale modeling of exotic nano-bio materials using novel computer simulation techniques. I implement the basic concept of statistical mechanics and computational chemistry to understand the phenomenon of technological interest at the nanoscale. The overall goal of my research is to broaden the usage of nanomaterials in modern science and technology. 

As Feynman once said, "If we could look at the thing, we can answer many of the questions of biology", I use a computational microscope to look at the molecular level structure of the biomolecules. The question I always ask in my research is that what can we learn about the molecular self-assembly and interactions of these biomolecules inside a tiny molecular machine i.e. a biological cell? Can we mimic the in-vivo behavior of these biological components outside a biological cell? I believe that if we can mimic the functionality of the biological cell, this will have a similar impact on human civilization as did by the invention of transistors in the previous century. 

Please refer to my curriculum vitae for detailed information about my education, skills, and research interest.

Publications

  1. Patrick M. Arnott, Himanshu Joshi, Aleksei Aksimentiev, and Stefan Howorka. "Dynamic Interactions between Lipid-Tethered DNA and Phospholipid Membranes." Langmuir 34:15084-15092 (2018). PDF icon supplementary_information.pdf (2.54 MB)
  2. Yiming Yang, Aaron Alford, Veronika Kozlovskaya, Shidi Zhao, Himanshu Joshi, Eunjung Kim, Shuo Qian, Volker Urban, Donald Cropek, Aleksei Aksimentiev, and Eugenia Kharlampieva. "Effect of temperature and hydrophilic ratio on the structure of poly(N-vinylcaprolactam)-block-poly(dimethylsiloxane)-block-poly(N-vinylcaprolactam) polymersomes." ACS Applied Polymer Materials 1:722-736 (2019). PDF icon si-aba_sans_revised.pdf (2.84 MB)
  3. Alexander Ohmann, Kerstin Göpfrich, Himanshu Joshi, Rebecca F. Thompson, Diana Sobota, Neil A. Ranson, Aleksei Aksimentiev, and Ulrich F. Keyser. "Controlling aggregation of cholesterol-modified DNA nanostructures." Nucleic Acid Research 47:11441-11451 (2019). PDF icon si.pdf (1.74 MB)
  4. Woochul Song, Himanshu Joshi, Ratul Chowdhury, Joseph S. Najem, Yue-xiao Shen, Chao Lang, Codey B. Henderson, Yu-Ming Tu, Megan Farell, Megan E. Pitz, Costas D. Maranas, Paul S. Cremer, Robert J. Hickey, Stephen A. Sarles, Jun-li Hou, Aleksei Aksimentiev, and Manish Kumar. "Artificial Water Channels Enable Fast and Selective Water Permeation Through Water-wire Networks." Nature Nanotechnology. 15,:73-79 (2020). PDF icon song2019_si.pdf (15.29 MB)
  5. Diana Sobota, Himanshu Joshi, Alexander Ohmann, Aleksei Aksimentiev, and Ulrich F. Keyser. "Tailoring interleaflet lipid transfer with a DNA-based synthetic enzyme." Nano Letters 20:4306-4311 (2020). PDF icon si.pdf (2.57 MB)
  6. Arundhati Roy, Himanshu Joshi, Ruijuan Ye, Jie Shen, Feng Chen, Aleksei Aksimentiev, and Huaqiang Zeng. "Polyhydrazide-based organic nanotubes as extremely efficient and highly selective artificial iodide channels." Angewandte Chemie International Edition 12:4806-4813 (2020). PDF icon si-final.pdf (3.1 MB)
  7. Prabhat Tripathi, Liang Shuai, Himanshu Joshi, Hirohito Yamazaki, William H. Fowle, Aleksei Aksimentiev, Hicham Fenniri, and Meni Wanunu. "Rosette Nanotube Porins as Ion Selective Transporters and Single-Molecule Sensors." Journal of the American Chemical Society 142:1680-1685 (2020). PDF icon si.pdf (2.47 MB)
  8. Adnan Choudhary, Himanshu Joshi, Han-Yi Chou, Kumar Sarthak, James Wilson, Christopher Maffeo, and Aleksei Aksimentiev. "High-Fidelity Capture, Threading, and Infinite-Depth Sequencing of Single DNA Molecules with a Double-Nanopore System." ACS Nano 14:15566-15576 (2020). PDF icon nn0c06191_si_001.pdf (547.55 KB)
  9. D Winogradoff, P‐Y Li, H Joshi, L Quednau, C Maffeo, and A Aksimentiev. "Chiral Systems Made from DNA." Advanced Science 8:2003113 (2021).
  10. Sioned F. Jones, Himanshu Joshi, Stephen J. Terry, Jonathan R. Burns, Aleksei Aksimentiev, Ulrike S. Eggert, and Stefan Howorka. "Hydrophobic Interactions between DNA Duplexes and Synthetic and Biological Membranes." J Am Chem Soc (2021). PDF icon si.pdf (20.33 MB)
  11. Arundhati Roy, Jie Shen, Himanshu Joshi, Woochul Song, Yu-Ming Tu, Ratul Chowdhury, Ye Ruijuan, Ning Li, Changliang Ren, Manish Kumar, Aleksei Aksimentiev, and Huaqiang Zeng. "Foldamer-Based Ultrapermeable and Highly Selective Artificial Water Channels that Exclude Protons." Nature nanotechnology (2021). PDF icon si.pdf (2.73 MB)
  12. Diana Morzy, Roger Rubio-Sánchez, Himanshu Joshi, Aleksei Aksimentiev, Lorenzo Di Michele, and Ulrich F. Keyser. "Cations Regulate Membrane Attachment and Functionality of DNA Nanostructures." Journal of the American Chemical Society (2021). PDF icon si.pdf (2.68 MB)
  13. Kristina Hübner, Himanshu Joshi, Aleksei Aksimentiev, Fernando D. Stefani, Philip Tinnefeld, and Guillermo P. Acuna. "Determining the In-Plane Orientation and Binding Mode of Single Fluorescent Dyes in DNA Origami Structures." ACS Nano 15:5109-5117 (2021). PDF icon si_published.pdf (1.28 MB)