Nanopores for single molecule detection and manipulation

Within just a decade of pioneering work demonstrating the utility of nanopores for molecular sensing, the field exploded with proposals for using nanopores as sensors, reactors, actuators, transducers, transporters, and other nanodevices. During the last five years, our work in this area has focused on developing a method for sequencing DNA, using solid-state nanopores for single-molecule force spectroscopy, and developing general methods for molecular simulations of such systems.