Error message

  • Notice: Trying to access array offset on value of type null in template_preprocess_jw_player() (line 414 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Warning: Illegal string offset 'uri' in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Notice: Uninitialized string offset: 0 in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Notice: Trying to access array offset on value of type null in template_preprocess_jw_player() (line 414 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Warning: Illegal string offset 'uri' in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Notice: Uninitialized string offset: 0 in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Notice: Trying to access array offset on value of type null in template_preprocess_jw_player() (line 414 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Warning: Illegal string offset 'uri' in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).
  • Notice: Uninitialized string offset: 0 in template_preprocess_jw_player() (line 423 of /home/bionano/public_html.devel/sites/all/modules/jw_player/jw_player.module).

Multi-resolution simulations of self-assembled DNA nanostructures

The DNA origami method has brought nanometer-precision fabrication to molecular biology labs, offering myriads of potential applications in the fields of synthetic biology, biomolecular medicine, molecular computation, etc. Advancing the method further requires controlling self-assembly down to the atomic scale. Hence, fast, accurate and detailed structure prediction can advance the development of complex, functional DNA origami constructs. Towards this goal, we developed a protocol that unites the rapid and robust structural relaxation of low-resolution coarse-grained modeling with the detail and accuracy of atomistic molecular dynamics simulation. In this tutorial we will show you how to use the multi-resolution DNA (mrdna) Python package to perform such simulations.

 

Example applications