Loomis Laboratory of Physics
1110 West Green Street
Shu-Han received his B.S. degree in physics from National Taiwan University in 2009. He is currently a PhD candidate in Physics Department and Center for the Physics of Living Cells (CPLC) and is co-advised by Professor Aleksei Aksimentiev (Physics) and Professor Martin Gruebele (Chemistry). His research interests lie at conformational dynamics of macromolecules and how macromolecules, like protein, carbohydrates or DNA, interact with the surrounding environment. He is now using both computational method (Molecular Dynamics simulation, Continuum modeling) and experimental method (fast temperature jump protein refolding, terahertz spectroscopy, circular dichroism spectroscopy) to study 1) PEG-aided stabilization of PEGylated proteins 2) DNA translocation through a solid-state nanopore under plasmonic field.
- Modeling thermophoretic effects in solid-state nanopores." Journal of Computational Electronics 13:826-838 (2014). "
- Two Structural Scenarios for Protein Stabilization by PEG." J Phys Chem B 118:8388-8395 (2014). "
- Filling Up the Heme Pocket Stabilizes Apomyoglobin and Speeds Up Its Folding." J Phys Chem B (2014). "
- Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA." ACS Nano 9:10598-10611 (2015). "
- Mapping fast protein folding with multiple-site fluorescent probes." Proc Natl Acad Sci U S A 112:7966-71 (2015). "