@article {204,
	title = {Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA},
	journal = {ACS Nano},
	volume = {9},
	year = {2015},
	month = {09/2015},
	pages = {10598--10611},
	type = {Article},
	abstract = {<p class="rtejustify">\&nbsp;\&nbsp;\&nbsp;\&nbsp;\&nbsp;\&nbsp;With the aim of developing a DNA sequencing methodology, we theoretically examine the feasibility of using nanoplasmonics to control the translocation of a DNA molecule through a solid-state nanopore and to read off sequence information using surface-enhanced Raman spectroscopy. Using molecular dynamics\&nbsp;simulations, we show that high-intensity optical hot spots produced by a metallic nanostructure can arrest DNA translocation through a solid-state nanopore, thus providing a physical knob for controlling the DNA speed. Switching the plasmonic field on and off can displace the DNA molecule in discrete steps, sequentially exposing neighboring fragments of a DNA molecule to the pore as well as to the plasmonic hot spot. Surface-enhanced Raman scattering from the exposed DNA fragments contains information about their nucleotide composition, possibly allowing the identification of the nucleotide sequence of a DNA molecule transported through the hot spot. The principles of plasmonic nanopore sequencing can be extended to detection of DNA modifications and RNA characterization.</p>
},
	doi = {10.1021/acsnano.5b04173},
	url = {http://pubs.acs.org/doi/10.1021/acsnano.5b04173},
	author = {Maxim Belkin and Shu-Han Chao and Magnus P. Jonsson and Cees Dekker and Aleksei Aksimentiev}
}
