• #330000
    Electro-Osmotic Flow Generation via a Sticky Ion Action
  • #99cccc
    Dehydrated Biomimetic Membranes with Skinlike Structure and Function
  • #000000
    Packaging pressurized dsDNA virus reveals genome organized in loops, not spools
  • #333333
  • #660033
    Aromatic residues facilitate electric current through proteins
  • #cc9900
    DNA turbine in nanopore switches rotation direction in high salt
  • #666666
    Benchmarking Molecular Dynamics Force Fields for All-Atom Simulations of Biological Condensates
  • #339999
    DNA double helix, a tiny electromotor
  • #000000
    Unidirectional single-file transport of full-length proteins through a nanopore
  • #006666
    Toward a physical model of a replisome
  • #993366
    Percolation controls passive transport through nuclear pores
  • #006699
    Resolving isomeric posttranslational modifications using a biological nanopore as a sensor of molecular shape
  • #990099
    Multiple rereads of single protein sequence
  • #00cccc
    Self-folding water filter
  • #262cc9
    Infinite-depth sequencing of single nucleic acid molecules
  • #003366
    Mrdna: Multi-resolution DNA modeling package blends speed and accuracy for structure determination
  • #0000cc
    Nanopore recognition of the twenty amino acids
  • #009999
    Predicting energy production of entire photosynthetic organelle from atomic simulations
  • #ff9933
    Artificial water channels enable rapid and selective water transport
  • #00ccff
    Guiding the capture of DNA molecules and proteins

Recent publications

The structure and physical properties of a packaged bacteriophage particle

Kush Coshic, Christopher Maffeo, David Winogradoff, and Aleksei Aksimentiev
Nature 627(8005) 905-914 (2024)
DOI:10.1038/s41586-024-07150-4  BibTex

A DNA turbine powered by a transmembrane potential across a nanopore

Xin Shi, Anna-Katharina Pumm, Christopher Maffeo, Fabian Kohler, Elija Feigl, Wenxuan Zhao, Daniel Verschueren, Ramin Golestanian, Aleksei Aksimentiev, Hendrik Dietz, and Cees Dekker
Nature Nanotechnology 19(3) 338-344 (2024)
DOI:10.1038/s41565-023-01527-8  BibTex

Molecular Determinants of Current Blockade Produced by Peptide Transport Through a Nanopore

Jingqian Liu, and Aleksei Aksimentiev
ACS Nanosci. Au 4(1) 21-29 (2024)
DOI:10.1021/acsnanoscienceau.3c00046  BibTex

Conformation-Dependent Hydrogen-Bonding Interactions in a Switchable Artificial Metalloprotein

Saman Fatima, Behzad Mehrafrooz, David G. Boggs, Noor Ali, Swapnil Singh, Megan C. Thielges, Jennifer Bridwell-Rabb, Aleksei Aksimentiev, and Lisa Olshansky
Biochemistry (2024)
DOI:10.1021/acs.biochem.4c00209  BibTex

Electro-Osmotic Flow Generation via a Sticky Ion Action

Behzad Mehrafrooz, Luning Yu, Laxmi Pandey, Zuzanna S. Siwy, Meni Wanunu, and Aleksei Aksimentiev
ACS nano 18(27) 17521-17533 (2024)
DOI:10.1021/acsnano.4c00829  BibTex

Dehydrated Biomimetic Membranes with Skinlike Structure and Function

Hyeonji Oh, Yu-Ming Tu, Laximicharan Samineni, Sophie De Respino, Behzad Mehrafrooz, Himanshu Joshi, Lynnicia Massenburg, Horacio Lopez-Marques, Nada Elessawy, Woochul Song, Harekrushna Behera, Raman Dhiman, Veda Sheersh Boorla, Kartik Kher, Yi-Chih Lin, Costas Maranas, Aleksei Aksimentiev, Benny D. Freeman, and Manish Kumar
ACS Applied Materials & Interfaces 16(16) 20865-20877 (2024)
DOI:10.1021/acsami.3c19572  BibTex

DNA double helix, a tiny electromotor

Christopher Maffeo, Lauren Quednau, James Wilson, and Aleksei Aksimentiev
Nature Nanotechnology 18 238-242 (2023)
DOI:10.1038/s41565-022-01285-z  BibTex

A Marcus-Type Inverted Region in the Translocation Kinetics of a Knotted Protein

Prabhat Tripathi, Behzad Mehrafrooz, Aleksei Aksimentiev, Sophie E. Jackson, Martin Gruebele, and Meni Wanunu
The Journal of Physical Chemistry Letters 14(47) 10719-10726 (2023)
DOI:10.1021/acs.jpclett.3c02183  BibTex

Long-Range Conductivity in Proteins Mediated by Aromatic Residues

Siddharth Krishnan, Aleksei Aksimentiev, Stuart Lindsay, and Dmitry Matyushov
ACS Physical Chemistry Au 3 444-455 (2023)
DOI:10.1021/acsphyschemau.3c00017  BibTex

Engineering Biological Nanopore Approaches toward Protein Sequencing

Xiaojun Wei, Tadas Penkauskas, Joseph E. Reiner, Celeste Kennard, Mark J. Uline, Qian Wang, Sheng Li, Aleksei Aksimentiev, Joseph W. F. Robertson, and Chang Liu
ACS Nano 17 16369-16395 (2023)
DOI:10.1021/acsnano.3c05628  BibTex