Loomis Laboratory of Physics
1110 West Green Street
Urbana, IL 61801-3080
Currently, I am a postdoctoral researcher in the Physics department at the University of Illinois at Urbana-Champaign with Professor Aleksei Aksimentiev. My focus is working at the cutting-edge of biophysics in collaboration with computational and experimentalist biologists to better connect simulation with experiment, with a specific focus on the selective transport of the nuclear pore complex, the electrical properties of DNA origami, and modelling chromatin. I want to better understand the biological implications and hypotheses we can develop from computational studies and to continue to explore fundamental questions about the nucleosome. My PhD was in Chemical Physics, specializing in computational biophysics with Professor Garegin Papoian at the University of Maryland in College Park. My doctoral research used atomistic molecular dynamics (MD) simulations to investigate an individual nucleosome, the fundamental packaging unit of DNA in higher-order organisms.
- Shearing of the CENP-A dimerization interface mediates plasticity in the octameric centromeric nucleosome." Scientific reports 5 (2015). "
- The acetylation landscape of the H4 histone tail: disentangling the interplay between the specific and cumulative effects." Journal of the American Chemical Society 137:6245-6253 (2015). "
- Promiscuous histone mis-assembly is actively prevented by chaperones." Journal of the American Chemical Society 138:13207-13218 (2016). "
- Molecular Mechanism of Spontaneous Nucleosome Unraveling." Journal of Molecular Biology 431:323-335 (2019). "
- The Oligomerization Landscape of Histones." Biophysical Journal 116:1845-1855 (2019). "