%0 Journal Article %J Nanotechnology %D 2013 %T Single-base DNA discrimination via transverse ionic transport. %A James Wilson %A Massimiliano Di Ventra %K Base Sequence %K DNA, Single-Stranded %K Ion Transport %K Ions %K Molecular Dynamics Simulation %K Nucleic Acid Conformation %X

We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.

%B Nanotechnology %V 24 %P 415101 %8 10/2013 %G eng %N 41 %R 10.1088/0957-4484/24/41/415101