@article {395,
	title = {A Marcus-Type Inverted Region in the Translocation Kinetics of a Knotted Protein},
	journal = {The Journal of Physical Chemistry Letters},
	year = {2023},
	month = {11/2023},
	pages = {10719-10726},
	abstract = {<p>Knotted proteins are rare but important species, yet how their complex topologies affect their physical properties is not fully understood. Here we combine single molecule nanopore experiments and all-atom MD simulations to study the electric-field-driven unfolding during the translocation through a model pore of individual protein knots important for methylating tRNA. One of these knots shows an unusual behavior that resembles the behavior of electrons hopping between two potential surfaces: as the electric potential driving the translocation reaction is increased, the rate eventually plateaus or slows back down in the {\textquotedblleft}Marcus inverted regime{\textquotedblright}. Our results shed light on the influence of topology in knotted proteins on their forced translocation through a pore connecting two electrostatic potential wells.</p>
},
	doi = {10.1021/acs.jpclett.3c02183},
	url = {https://doi.org/10.1021/acs.jpclett.3c02183},
	author = {Tripathi, Prabhat and Mehrafrooz, Behzad and Aksimentiev, Aleksei and Jackson, Sophie E. and Gruebele, Martin and Wanunu, Meni}
}
