@article {370,
	title = {Fluorofoldamer-Based Salt- and Proton-Rejecting Artificial Water Channels for Ultrafast Water Transport.},
	journal = {Nano Lett},
	volume = {22},
	year = {2022},
	month = {2022 06 22},
	pages = {4831-4838},
	abstract = {<p>Here, we report on a novel class of fluorofoldamer-based artificial water channels (AWCs) that combines excellent water transport rate and selectivity with structural simplicity and robustness. Produced by a facile one-pot copolymerization reaction under mild conditions, the best-performing channel (AWC ) is an n-CH-decorated foldamer nanotube with an average channel length of 2.8 nm and a pore diameter of 5.2 {\r A}. AWC demonstrates an ultrafast water conduction rate of 1.4 {\texttimes} 10 HO/s per channel, outperforming the archetypal biological water channel, aquaporin 1, while excluding salts (i.e., NaCl and KCl) and protons. Unique to this class of channels, the inwardly facing C(sp2)-F atoms being the most electronegative in the periodic table are proposed as being critical to enabling the ultrafast and superselective water transport properties by decreasing the channel{\textquoteright}s cavity and enhancing the channel wall smoothness via reducing intermolecular forces with water molecules or hydrated ions.</p>
},
	keywords = {Aquaporins, Biological Transport, Protons, Sodium Chloride, Water},
	issn = {1530-6992},
	doi = {10.1021/acs.nanolett.2c01137},
	author = {Shen, Jie and Roy, Arundhati and Joshi, Himanshu and Samineni, Laxmicharan and Ye, Ruijuan and Tu, Yu-Ming and Song, Woochul and Skiles, Matthew and Kumar, Manish and Aleksei Aksimentiev and Zeng, Huaqiang}
}
@article {351,
	title = {Foldamer-Based Ultrapermeable and Highly Selective Artificial Water Channels that Exclude Protons},
	journal = {Nature Nanotechnology},
	volume = {16},
	year = {2021},
	month = {08/2021},
	pages = {911-917},
	chapter = {911},
	abstract = {<p class="rtejustify">The outstanding capacity of aquaporins (AQPs) for mediating highly selective superfast water transport has inspired the recent development of supramolecular monovalent ion-excluding artificial water channels (AWCs). AWC-based bioinspired membranes are proposed for desalination, water purification, and other separation applications. While some recent progress has been made in synthesizing AWCs that approach the water permeability and ion selectivity of AQPs, a hallmark feature of AQPs{\textemdash}high water transport while excluding protons-has not been reproduced. We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 {\texttimes} 10<sup>10 </sup>water molecules per second for AQP1, with high water-over- monovalent-ion transport selectivity (~108 water molecules over Cl-\&nbsp;ion) conferred by the modularly tunable hydrophobicity of the interior pore surface. The best-performing AWC reported here delivers water transport at an exceptionally high rate, namely, 2.5 times that of AQP1, while concurrently rejecting salts (NaCl and KCl) and even protons.</p>
},
	doi = {10.1038/s41565-021-00915-2},
	author = {Roy, Arundhati and Shen, Jie and Joshi, Himanshu and Song, Woochul and Tu, Yu-Ming and Chowdhury, Ratul and Ruijuan, Ye and Li, Ning and Ren, Changliang and Kumar, Manish and Aleksei Aksimentiev and Zeng, Huaqiang}
}
