@article {290,
	title = {PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore},
	journal = {Nature Communications},
	volume = {9},
	year = {2018},
	month = {09/2018},
	pages = {3661},
	abstract = {<p>Monodispersed angstrom-size pores embedded in a suitable matrix are promising for highly selective membrane-based separations. They can provide substantial energy savings in water treatment and small molecule bioseparations. Such pores present as membrane proteins (chiefly aquaporin-based) are commonplace in biological membranes but difficult to implement in synthetic industrial membranes and have modest selectivity without tunable selectivity. Here we present PoreDesigner, a design workflow to redesign the robust beta-barrel Outer Membrane Protein F as a scaffold to access three specific pore designs that exclude solutes larger than sucrose (\&gt;360 Da), glucose (\&gt;180 Da), and salt (\&gt;58 Da) respectively. PoreDesigner also enables us to design any specified pore size (spanning 3{\textendash}10 {\r A}), engineer its pore profile, and chemistry. These redesigned pores may be ideal for conducting sub-nm aqueous separations with permeabilities exceeding those of classical biological water channels,\&nbsp;aquaporins, by more than an order of magnitude at over 10 billion water molecules per channel per second.</p>
},
	issn = {2041-1723},
	doi = {10.1038/s41467-018-06097-1},
	url = {https://doi.org/10.1038/s41467-018-06097-1},
	author = {Chowdhury, Ratul and Ren, Tingwei and Shankla, Manish and Decker, Karl and Grisewood, Matthew and Prabhakar, Jeevan and Baker, Carol and Golbeck, John H and Aleksei Aksimentiev and Kumar, Manish and Maranas, Costas D}
}
