@article {27,
	title = {DNA base-calling from a nanopore using a Viterbi algorithm},
	journal = {Biophys J},
	volume = {102},
	year = {2012},
	month = {2012 May 16},
	pages = {L37-9},
	abstract = {<p>Nanopore-based DNA sequencing is the most promising third-generation sequencing method. It has superior read length, speed, and sample requirements compared with state-of-the-art second-generation methods. However, base-calling still presents substantial difficulty because the resolution of the technique is limited compared with the measured signal/noise ratio. Here we demonstrate a method to decode 3-bp-resolution nanopore electrical measurements into a DNA sequence using a Hidden Markov model. This method shows tremendous potential for accuracy (~98\%), even with a poor signal/noise ratio.</p>},
	keywords = {Algorithms, Base Sequence, DNA, Electricity, Genome, Human, Humans, Markov Chains, Nanopores, Sequence Analysis, DNA, Signal-To-Noise Ratio},
	issn = {1542-0086},
	doi = {10.1016/j.bpj.2012.04.009},
	author = {Timp, Winston and Jeffrey Comer and Aleksei Aksimentiev}
}
