@article {147,
	title = {Conformational transitions and stop-and-go nanopore transport of single-stranded DNA on charged graphene},
	journal = {Nature Communications},
	volume = {5},
	year = {2014},
	pages = {5171},
	abstract = {<p>Control over interactions with biomolecules holds the key to applications of graphene in biotechnology. One such application is nanopore sequencing, where a DNA molecule is electrophoretically driven through a graphene nanopore. Here we investigate how interactions of single-stranded DNA and a graphene membrane can be controlled by electrically biasing the membrane. The results of our molecular dynamics simulations suggest that electric charge on graphene can force a DNA homopolymer to adopt a range of strikingly different conformations. The conformational response is sensitive to even very subtle nucleotide modifications, such as DNA methylation. The speed of DNA motion through a graphene nanopore is strongly affected by the graphene charge: a positive charge accelerates the motion, whereas a negative charge arrests it. As a possible application of the effect, we demonstrate stop-and-go transport of DNA controlled by the charge of graphene. Such on-demand transport of DNA is essential for realizing nanopore sequencing.</p>
},
	issn = {2041-1723},
	doi = {10.1038/ncomms6171},
	url = {http://www.nature.com/ncomms/2014/141009/ncomms6171/full/ncomms6171.html},
	author = {Shankla, Manish and Aleksei Aksimentiev}
}
